Mixed infection of an atypical Mycobacterium and Aspergillus following a cryopreserved fat graft to a face.

TitleMixed infection of an atypical Mycobacterium and Aspergillus following a cryopreserved fat graft to a face.
Publication TypeJournal Article
Year of Publication2013
AuthorsKim SK, Kim HJ, Hwang K
JournalThe Journal of craniofacial surgery// J Craniofac Surg
Volume24
Issue5
Pagination1676 - 8
Date Published2013//
ISBN Number1536-3732
Other Numbersa3j, 9010410
Keywords*Adipose Tissue/tr [Transplantation], *Aspergillosis/et [Etiology], *Face/su [Surgery], *Mycobacterium Infections, Nontuberculous/et [Etiology], *Transplantation, Autologous/ae [Adverse Effects], Abscess/su [Surgery], Aspergillus/ip [Isolation & Purification], Chronic Disease, Coinfection/mi [Microbiology], Cryopreservation, Female, Humans, Nontuberculous Mycobacteria/ip [Isolation & Purification], Postoperative Complications, Tissue Preservation, Young Adult
Abstract

We report a chronic infection of a patient who received a cryopreserved fat graft on her face. A 22-year-old female patient presented with multiple abscesses of her face. Four months previously, she received a second fat graft with the fat harvested at a previous surgery which was cryopreserved for 2 months. On examination, she had tender erythematous nodules on both cheeks. A computed tomography of her neck showed multiple peripheral enhancing nodular lesions. In an open pus fungus culture, Aspergillus fumigatus growth was observed. On the Mycobacterium Other Than Tuberculosis identification PCR, Mycobacterium fortuitum was found. She was treated with levofloxacin, clarithromycin, and minocycline for 11 months, and finally the symptoms subsided. To avoid infection after the fat graft, cryopreserved fat should not be used as a possible grafting material. In cases of persistent infection, or in cases of waxes and gains after drainage of pus and short-term antibiotics therapy, atypical Mycobacterium or Aspergillus should be suspected and a PCR for them should be carried out.

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