| Title | Frequent detection of viral nucleic acids in heart valve tissue |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Donoso Mantke O, Meyer R, Prosch S, Niedrig M |
| Journal | Journal of clinical microbiology |
| Volume | 42 |
| Issue | 5 |
| Pagination | 2298 - 300 |
| Date Published | May |
| Type of Article | Research Support, Non-U.S. Gov't |
| ISSN | 0095-1137 (Print) 0095-1137 (Linking) |
| Accession Number | 15131218 |
| Keywords | Adolescent, Adult, Bioprosthesis / adverse effects / *virology, Child, DNA, Viral / genetics / *isolation & purification, Female, Heart Valve Prosthesis / adverse effects / *virology, Humans, Male, Middle Aged, Polymerase Chain Reaction, Risk Factors, Safety, Tissue Donors, Transplantation, Homologous, Virus Diseases / transmission |
| Abstract | Due to a paucity of published data concerning the prevalence of viral nucleic acid in homografts, we analyzed tissue from 30 donor hearts for the presence of viral genome sequences of enteroviruses, adenoviruses, human cytomegalovirus, and influenza virus using different PCR techniques. Viral DNA was amplified in 64 and 52% of the subvalvular myocardial tissue and non-coronary valve samples, respectively. These findings, compared with clinical history and histologic and serologic analysis, demonstrate the importance of viral safety measures in heart valve banking. |
| Alternate Journal | J Clin Microbiol |
| Notify Library Reference ID | 449 |
