Human T lymphotropic virus type-1-associated myelopathy manifesting shortly after living-donor renal transplantation.

TitleHuman T lymphotropic virus type-1-associated myelopathy manifesting shortly after living-donor renal transplantation.
Publication TypeJournal Article
Year of Publication2015
AuthorsNagamine Y, Hayashi T, Kato Y, Horiuchi Y, Tanahashi N
JournalInternal medicine (Tokyo, Japan)// Intern Med
Volume54
Issue1
Pagination75 - 8
Date Published2015//
ISBN Number1349-7235
Other Numbersbd6, 9204241
Keywords*Antiviral Agents/tu [Therapeutic Use], *Human T-lymphotropic virus 1/py [Pathogenicity], *Interferon-alpha/tu [Therapeutic Use], *Kidney Transplantation/ae [Adverse Effects], *Living Donors, *Paraparesis, Tropical Spastic/dt [Drug Therapy], *Paraparesis, Tropical Spastic/vi [Virology], Adult, Female, Humans, Paraparesis, Tropical Spastic/di [Diagnosis], Treatment Outcome
Abstract

A 38-year-old woman experienced numbness in both lower extremities and spastic paralysis a few months after undergoing living-donor renal transplantation. The patient was negative for human T lymphotropic virus type-1 (HTLV-1) antibodies prior to the procedure; however, she was diagnosed with HTLV-1-associated myelopathy (HAM) based on positive serum and cerebrospinal fluid antibody titers after the surgery. Because the donor was also positive for HTLV-1 antibodies, the infection likely originated from the transplanted kidney. Clinical and imaging improvements were noted following the administration of interferon-alpha. HAM has been reported to occur after living-donor renal transplantation; however, there are no previous reports of onset within such a short period.
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