HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient.

TitleHBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient.
Publication TypeJournal Article
Year of Publication2013
AuthorsCoppola N, Loquercio G, Tonziello G, Azzaro R, Pisaturo M, Di Costanzo G, Starace M, Pasquale G, Cacciapuoti C, Petruzziello A
JournalJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology// J Clin Virol
Volume58
Issue1
Pagination315 - 7
Date Published2013//
ISBN Number1873-5967
Other Numberscx0, 9815671
Keywords*Blood Component Transfusion/ae [Adverse Effects], *Carrier State/vi [Virology], *Hepatitis B Surface Antigens/ge [Genetics], *Hepatitis B/di [Diagnosis], *Hepatitis B/tm [Transmission], *Immunocompromised Host, *Mutation, Missense, Aged, Carrier State/di [Diagnosis], DNA, Viral/bl [Blood], Hepatitis B Surface Antigens/bl [Blood], Hepatitis B/vi [Virology], Humans, Male, Viral Load
Abstract

We describe the case of transmission of an HBsAg-negative hepatitis B infection to an immunosuppressed patient by plasma donation from an HBsAg-negative subject, but with very low serum HBV DNA (about 50 IU/ml) and five mutations in the major hydrophilic region of HBsAg.Copyright © 2013. Published by Elsevier B.V.
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