| Title | Marginal keratitis associated with administration of filgrastim and sargramostim in a healthy peripheral blood progenitor cell donor |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Esmaeli B, Ahmadi MA, Kim S, Onan H, Korbling M, Anderlini P |
| Journal | Cornea |
| Volume | 21 |
| Issue | 6 |
| Pagination | 621 - 2 |
| Abstract | PURPOSE: To describe a 61-year-old healthy peripheral blood progenitor cell (PBPC) donor who developed marginal keratitis and mild uveitis on the third day after receiving daily recombinant human granulocyte colony-stimulating factor (rhG-CSF; filgrastim) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF; sargramostim) to mobilize PBPCs for allogeneic transplantation. METHODS: Interventional case report. RESULTS: The keratitis was treated with topical administration of 1% prednisolone acetate solution and resolved within 24 hours. The topical steroid dose was tapered and ultimately discontinued without recurrence of keratitis. CONCLUSION: Healthy PBPC donors receiving rhG-CSF or rhGM-CSF should be monitored for ocular complications, particularly marginal keratitis and uveitis. |
| Short Title | Marginal keratitis associated with administration of filgrastim and sargramostim in a healthy peripheral blood progenitor cell donor |
| Notify Library Reference ID | 488 |
