| Title | Efficacy of induction therapy in cadaveric renal transplantation comparing rabbit antithymocyte serum and Minnesota antilymphoblast globulin |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Authors | Fisher RA, Tchervenkov JI, Schroeder TJ, Alexander JW, Munda R, Penn I, Carey M, First MR |
| Journal | Transplant Proc |
| Volume | 23 |
| Issue | 1 Pt 2 |
| Pagination | 1253 - 5 |
| Date Published | Feb |
| Accession Number | 1989203 |
| Keywords | Adult, Animals, Antigens, CD / analysis, Antilymphocyte Serum / *standards, Cadaver, Comparative Study, Female, Graft Rejection, Graft Survival, Humans, Immunosuppression / *methods, Kidney Transplantation / immunology / *methods, Male, Opportunistic Infections / complications, Rabbits, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Survival Analysis, T-Lymphocyte Subsets / immunology |
| Abstract | From August 1986 to July 1989, 98 patients receiving primary cadaveric kidney transplants received either RATS (n = 50) or MALG (n = 48) during the induction phase of a quadruple immunosuppressive protocol. Patient groups were well matched. The duration of RATS and MALG treatment and the time of CyA induction were equivalent. Serum creatinine and rejection episodes up to 1 year were not statistically different. Hematologic side effects resulted in dose reduction of MALG in 42% of patients without adverse rejection results. In the RATS group, no dosage reductions were required. One-year patient survivals (96% to 100%), and 1-year graft survival (82% to 85%) were not significantly different in the 2 groups. Infectious complications were 30% higher in the MALG group and a significant factor in 2 deaths. Monitoring of lymphocyte subsets revealed insignificant differences in the percent of decrease of each cell population between MALG and RATS groups during induction. |
| Notify Library Reference ID | 524 |
