First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation

TitleFirst report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation
Publication TypeJournal Article
Year of Publication2005
AuthorsFraser CJ, Hirsch BA, Dayton V, Creer MH, Neglia JP, Wagner JE, Baker KS
JournalBlood
Volume106
Issue13
Pagination4377 - 80
Date PublishedDec 15
ISSN0006-4971 (Print) 0006-4971 (Linking)
Accession Number16118319
Keywords*Blood Donors, *Umbilical Cord, Acute Disease, Chromosomes, Human, Pair 22 / genetics, Cord Blood Stem Cell Transplantation / *adverse effects, Cytogenetics, Humans, Infant, Leukemia / *etiology / genetics / *pathology, Male
Abstract

Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation. A 12-month-old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. Forty months after transplantation, he developed acute myeloid leukemia. Cytogenetic and molecular analysis confirmed donor cell origin. The Cord Blood Bank (CBB) contacted the donor's family and established that the child, now 7 years old, was healthy. This represents the first reported case of donor cell leukemia following UCBT. This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients.

DOI10.1182/blood-2005-06-2551
Notify Library Reference ID543

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