A giant multiacinar macroregenerative nodule in an explanted liver

TitleA giant multiacinar macroregenerative nodule in an explanted liver
Publication TypeJournal Article
Year of Publication2001
AuthorsGurkan A, Sherlock MF, Chui AK, Thomson R, Verran D, Sheil AG, Painter D
JournalTransplantation
Volume72
Issue3
Pagination538 - 9
Date PublishedAug 15
Accession Number11502992
Keywords*Liver Transplantation, Adult, Diagnosis, Differential, Female, Humans, Hyperplasia, Liver / *pathology, Liver Diseases / *pathology / *surgery, Precancerous Conditions / *pathology / *surgery
Abstract

Macroregenerative nodules (MRN) have been detected with increased incidence in explanted livers since orthotopic liver transplantation (OLTx) has become a routine treatment for end-stage liver disease. Autopsy series suggest that MRN may be more common than once thought, and several studies point to the malignant potential of these lesions. With increasing waiting times for OLTx, the propensity for these premalignant lesions to arise in cirrhotic livers has important implications for the supervision of patients on OLTx waiting lists. We present here a striking example of a MRN and review a topic that is generating considerable interest.

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