Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient

TitleTreatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient
Publication TypeJournal Article
Year of Publication2009
AuthorsHuston JM, Eachempati SR, Rodney JR, Cayci C, Fusco D, Mathew M, Shou J, Goldstein MJ, Kapur S, Barie PS
JournalTranspl Infect Dis
Volume11
Issue3
Pagination277 - 80
Date PublishedJun
ISSN1399-3062 (Electronic) 1398-2273 (Linking)
Accession Number19392733
KeywordsAged, 80 and over, Albendazole / therapeutic use, Animals, Anti-Infective Agents / therapeutic use, Drug Therapy, Combination, Female, Fibrinolytic Agents / administration & dosage / *therapeutic use, Humans, Ivermectin / therapeutic use, Kidney Transplantation / *adverse effects, Klebsiella Infections / complications / microbiology, Klebsiella pneumoniae / drug effects, Penicillanic Acid / analogs & derivatives / therapeutic use, Piperacillin / therapeutic use, Protein C / administration & dosage / *therapeutic use, Recombinant Proteins / administration & dosage / therapeutic use, Respiratory Distress Syndrome, Adult / *drug therapy, Shock, Septic / *drug therapy, Strongyloides stercoralis / *drug effects, Strongyloidiasis / *complications / drug therapy / parasitology, Superinfection / *complications / microbiology / parasitology, Treatment Outcome
Abstract

We report a case of Strongyloides stercoralis hyperinfection syndrome in a renal transplant recipient complicated by septic shock, acute respiratory distress syndrome, and Klebsiella pneumoniae superinfection. The patient was treated successfully with drotrecogin alfa (activated), parenteral ivermectin, albendazole, and piperacillin/tazobactam. This outcome suggests that drotrecogin alfa (activated) may be useful therapy for transplant recipients who develop severe sepsis or septic shock secondary to potentially lethal opportunistic infections.

DOI10.1111/j.1399-3062.2009.00386.x
Short TitleTreatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient
Notify Library Reference ID711

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