Collection of allogeneic peripheral blood stem cells.

TitleCollection of allogeneic peripheral blood stem cells.
Publication TypeJournal Article
Year of Publication1999
AuthorsKörbling M
JournalBaillieres Best Pract Res Clin Haematol
Pagination41 - 55
Date Published1999 Mar-Jun
Accession Number11000982
KeywordsAnimals, Antigens, CD34, Blood Component Removal, Cytokines, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cells, Humans, Transplantation, Homologous

Circulating stem cells from healthy donors are increasingly used for allogeneic transplantation in patients with malignant lymphohaematopoietic disorders and solid tumours. Stem cells are collected by single or multiple aphereses following cytokine treatment. In the following, the effects of rhG-CSF on peripheral blood CD34+ cell and subset concentrations are described, as well as rhG-CSF related side-effects observed in normal donors. Safety considerations regarding cytokine treatment of normal donors are listed. The stem cell apheresis technology and cell yields are presented. Finally, novel aspects of stem cell mobilization, including the use of Flt3 ligand and anti-VLA4/VCAM-1 antibodies, are discussed.

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