[The characteristics of Trypanosoma cruzi strains isolated from patients who have undergone a heart transplant]

Title[The characteristics of Trypanosoma cruzi strains isolated from patients who have undergone a heart transplant]
Publication TypeJournal Article
Year of Publication1995
AuthorsLanura PN, Matsubara L, Amato Neto V, Okumura M, Bocchi EA
JournalRev Soc Bras Med Trop
Volume28
Issue4
Pagination351 - 6
Date PublishedOct-Dec
ISSN0037-8682 (Print) 0037-8682 (Linking)
Accession Number8668835
Keywords*Heart Transplantation, Adolescent, Adult, Animals, Chagas Cardiomyopathy / parasitology / pathology / surgery, Disease Models, Animal, Feces / parasitology, Female, Humans, Male, Mice, Mice, Inbred BALB C, Parasitemia / parasitology / pathology, Postoperative Period, Time Factors, Trypanosoma cruzi / *isolation & purification / pathogenicity
Abstract

Three strains of Trypanosoma cruzi were isolated from Chagas' disease patients transplanted for heart failure, after cardiac transplantation, and were studied in an experimental model of Chagas' disease, in mice, with evaluation of parasitic load, mortality and extension of inflammatory infiltrates in the heart. These parameters were compared with the standard strain Y. The strains had differences in the studied parameters, but there was no clear relationship between those and post-transplant evolution of the patients. Probably the clinical response is multifactorial and derives only in part from biological characteristics of the infecting T. cruzi strain, as measured in our model.

Short Title[The characteristics of Trypanosoma cruzi strains isolated from patients who have undergone a heart transplant]
Notify Library Reference ID867

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