Post-transplant lymphoproliferative disorder

TitlePost-transplant lymphoproliferative disorder
Publication TypeJournal Article
Year of Publication2005
AuthorsLoren AW, Tsai DE
JournalClin Chest Med
Pagination631 - 45, - vii
Date PublishedDec
Accession Number16263402
KeywordsHematopoietic Stem Cell Transplantation / *adverse effects, Humans, Lymphoproliferative Disorders / *etiology, Organ Transplantation / *adverse effects, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Post-transplant lymphoproliferative disorder (PTLD) is an increasingly recognized complication of solid organ and hematopoietic stem cell transplantation. PTLD represents a spectrum of polyclonal and monoclonal lymphoproliferation, generally of B cells. Prompt diagnosis is key and requires a high index of suspicion. An increasing variety of highly effective therapies, including immune modulation via reduction in immunosuppression, monoclonal antibodies, and cellular therapy, have dramatically improved the cure rates of this once devastating disease.

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