Graft vs Host disease

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Skin rash, fever, diarrhea, liver dysfunction, severe pancytopenia. Death due to sepsis and multi-organ failure.
Demonstration of imputability or root cause: 
It can be important to have a high index of suspicion and to confirm the diagnosis early with tests for donor chimerism.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
Smith, DM, et al, 2006. Graft-vs-host disease as a complication of lung transplantation. J Heart Lung Transplant 25:1175-7.