Graft-vs-host disease as a complication of lung transplantation.

TitleGraft-vs-host disease as a complication of lung transplantation.
Publication TypeJournal Article
Year of Publication2006
AuthorsSmith DM, Agura ED, Ausloos K, W Ring S, Domiati-Saad R, Klintmalm GB
JournalThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation//J Heart Lung Transplant
Pagination1175 - 7
Date Published2006
ISBN Number1557-3117
Other Numbersa0q, 9102703
Keywords*Graft vs Host Disease/et [Etiology], *Lung Transplantation/ae [Adverse Effects], *Postoperative Complications/im [Immunology], Chimerism, Diagnosis, Differential, Disease Progression, Fatal Outcome, Graft vs Host Disease/di [Diagnosis], Graft vs Host Disease/im [Immunology], Histocompatibility Testing, Humans, Lung Transplantation/im [Immunology], Lung Transplantation/pa [Pathology], Male, Middle Aged, Postoperative Complications/di [Diagnosis], T-Lymphocytes/pa [Pathology], Tissue Donors

We report a rare case of acute graft-vs-host disease (aGVHD) after a lung transplant. The patient presented with advanced disease manifested by skin rash, fever, diarrhea, liver dysfunction and severe pancytopenia. He went on to die of sepsis and multi-organ failure. aGVHD is a disease often confused with drug reactions or viral infection; therefore, it is important to have a high index of suspicion and to confirm the diagnosis early with tests for donor cell chimerism. Effective treatment is elusive but we are learning a great deal about the underlying mechanisms of this disease and hope to develop better treatment.

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