Delayed Hemolytic Transfusion Reaction (DHTR), anti-Ce+e

Status:

Ready to upload

Record number:

1632

Adverse Occurrence type:

Delayed Hemolytic Reaction

MPHO Type:

Red blood cells

Time to detection:

4 days

Alerting signals, symptoms, evidence of occurrence:

Back pain, fever, and hemoglobinuria occurred 4 days after receiving 2 incompatible units. Hemoglobinuria persisted for 5 days preceded by oliguria and a rising blood urea nitrogen (BUN), creatinine and bilirubin.

Demonstration of imputability or root cause:

An anti-Ce+e was detected retrospectively, pre-transfusion, and easily detected post transfusion.

Imputability grade:

2 Probable

Groups audience:

Clinical complications

Keywords:

DHTR (delayed hemolytic transfusion reaction)

BUN (blood urea nitrogen)

Rh (Rhesus) antibodies

anti-Ce+e

References:

An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function.

Reference attachment:

AHTR anti-C, Molthan, 1984.pdf

Suggest references:

Molthan, L, Matulewicz, TJ, Bansal-Carver, B and Benz, EJ. (1984). An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. Vox Sang 47:348-53

Expert comments for publication:

Rh (D) antibodies often have the capacity to cause severe immediate or delayed extravascular hemolytic transfusion reactions and all Rh antibodies should be considered to be potentially clinically significant. Rh antibodies include: D, C, C(w), E, c, e, e(8), Ce, f, Go(a), G, V (Rh 10), Rh17, Rh29, RH19.