An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function.

TitleAn immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function.
Publication TypeJournal Article
Year of Publication1984
AuthorsMolthan L, Matulewicz TJ, Bansal-Carver B, Benz EJ
JournalVox sanguinis//Vox Sang
Volume47
Issue5
Pagination348 - 53
Date Published1984
ISBN Number0042-9007
Other Numbersxli, 0413606
Keywords*Blood Group Incompatibility/et [Etiology], *Blood Transfusion/ae [Adverse Effects], *Rh-Hr Blood-Group System/im [Immunology], Aged, Blood Group Incompatibility/im [Immunology], Female, Hemoglobinuria/et [Etiology], Hemolysis, Humans, Immunoglobulin G/im [Immunology], Immunoglobulin M/im [Immunology], Isoantibodies/im [Immunology], Kidney Diseases/et [Etiology], Male, Middle Aged, Time Factors
Abstract

A patient with phenotype R2r and anti-C has a hemolytic transfusion reaction (HTR) with hemoglobinemia and hemoglobinuria which occurred within 2 h of receiving an R1r transfusion. Transient impaired renal function ensued. A patient with phenotype R2R2 and anti-Ce+e had the same experience on day 4 after receiving three R1r and one rr units. 2 other patients, 1 R2r with anti-C who received one R1r unit and the other R2R2 with anti-Ce+e who received two R1r units, showed no clinical evidence of HTR. Both anti-C antibodies were entirely IgG while both anti-Ce+e antibodies initially were predominantly IgM. IgG subclassing was unsuccessful and red blood cell-mononuclear phagocyte assays were normal. These cases occurred from 1979 to 1981.
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