Plateletpheresis-associated lymphopenia

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Seems to be rare, and to be limited to donors with ages over 55 years, who had frequent donations within a 365 days period and who had multiple donations in their lifetime. The study found that the CD4+ were <200 cells/microliter in 2 out of 20 donors with 3 to 19 donations in the past year, and in 6 out of 20 donors with 20 to 24 donations in the past year.
Time to detection: 
Unknown; it is possible that some donors had lymphopenia for months or years prior to its discovery.
Alerting signals, symptoms, evidence of occurrence: 
There are no associated signs/symptoms of the plateletpheresis-associated lymphopenia, and no apparent adverse effect on the donors' health.
Demonstration of imputability or root cause: 
Most likely caused by recurrent removal of T-lymphocytes by the leukoreduction chamber of the apheresis instrument.
Groups audience: 
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Suggest references: 
1) Plateletpheresis-associated lymphopenia in frequent platelet donors. Gansner JM, et al. Blood. 2019 Feb 7;133(6):605-614 2) CD4+ T-cell lymphopenia in frequent platelet donors who have ceased platelet donation for at least 1 year. Rahmani M, et al. Transfusion. 2019 May;59(5):1644-1647