Changes in blood counts after the administration of granulocyte-colony-stimulating factor and the collection of peripheral blood stem cells from healthy donors

TitleChanges in blood counts after the administration of granulocyte-colony-stimulating factor and the collection of peripheral blood stem cells from healthy donors
Publication TypeJournal Article
Year of Publication1996
AuthorsStroncek DF, Clay ME, Smith J, Ilstrup S, Oldham F, McCullough J
JournalTransfusion
Volume36
Issue7
Pagination596 - 600
Date PublishedJul
ISSN0041-1132 (Print) 0041-1132 (Linking)
Accession Number8701454
Keywords*Hematopoietic Stem Cell Transplantation, *Tissue Donors, Adult, Aspirin / contraindications, Filgrastim, Follow-Up Studies, Granulocyte Colony-Stimulating Factor / adverse effects / *pharmacology, Hematocrit, Hemorrhagic Disorders / chemically induced, Humans, Leukocyte Count / *drug effects, Neutropenia / chemically induced, Platelet Count / drug effects, Recombinant Proteins / adverse effects / pharmacology, Safety, Thrombocytopenia / chemically induced, Time Factors
Abstract

BACKGROUND: After the collection of granulocyte-colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cells from healthy donors, the donor platelet counts fall. However, the magnitude and duration of this decrease are not known. STUDY DESIGN AND METHODS: Sixty healthy people were given G-CSF (5, 7.5, or 10 micrograms/kg/day) for 5 days (Days 1-5), and 1 peripheral blood stem cell component was collected on Day 6. The platelet count, white cell count, absolute neutrophil count, hematocrit, and red cell count were measured before administration of G-CSF (Day 0), before collection of peripheral blood stem cells on Day 6, and on Days 8, 10, 13, 16, and 20. RESULTS: The platelet count fell from 261 +/- 47 x 10(9) cells per L on Day 0 to 159 +/- 30 x 10(9) cells per L on Day 8 (p

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