Thrombocytopenia

Record number:

893

Adverse Occurrence type:

GCSF-related

MPHO Type:

Apheresis

Estimated frequency:

Common

Alerting signals, symptoms, evidence of occurrence:

Thrombocyopenia, resulting in petechiae, bleeding, following administration of GCSF and apheresis collections. Identified by CBC. May require allogeneic platelet transfusion

Demonstration of imputability or root cause:

Probable. Temporal relationship to GCSF.

Keywords:

thrombocytopenia

CBC (complete blood count)

petechiae

bleeding

PBSC (peripheral blood stem cells)

G-CSF (granulocyte colony-stimulating factor)

apheresis

donor reaction

allogeneic

References:

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors

Treatment of normal donors with rhG-CSF 16 micrograms/kg for mobilization of peripheral blood stem cells and their apheretic collection for allogeneic transplantation

Efficacy and toxicity of a high-dose G-CSF schedule for peripheral blood progenitor cell mobilization in healthy donors

Acceptance and feasibility of peripheral stem cell mobilisation compared to bone marrow collection from healthy unrelated donors

Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: a single institution prospective study

Peripheral blood mononuclear cell collection from patients undergoing adoptive immunotherapy or peripheral blood-derived stem cell transplantation and from healthy donors

Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis

Comparison between once a day vs twice a day G-CSF for mobilization of peripheral blood progenitor cells (PBPC) in normal donors for allogeneic PBPC transplantation

Thrombocytopenia in allogeneic peripheral blood stem cell collections

Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints

Follow-up of healthy donors receiving granulocyte colony-stimulating factor for peripheral blood progenitor cell mobilization and collection. Results of the Spanish Donor Registry

rHuG-CSF increases the platelet-neutrophil complex formation and neutrophil adhesion molecule expression in volunteer granulocyte and stem cell apheresis donors

Filgrastim mobilization and collection of allogeneic blood progenitor cells from adult family donors: first interim report of a prospective German multicenter study

Changes in blood counts after the administration of granulocyte-colony-stimulating factor and the collection of peripheral blood stem cells from healthy donors

Treatment of normal individuals with granulocyte-colony-stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells

Prolonged thrombocytopenia after administration of granulocyte colony-stimulating factor and leukapheresis in a donor for allogeneic peripheral blood stem cell transplantation

Recovery and safety profiles of marrow and PBSC donors: experience of the National Marrow Donor Program.

World Marrow Donor Association. Clinical Working Group (S(P)EAR committee). Minneapolis 2012

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